Muscle Gene Expression Patterns in Human Rotator Cuff Pathology
نویسندگان
چکیده
منابع مشابه
Muscle gene expression patterns in human rotator cuff pathology.
BACKGROUND Rotator cuff pathology is a common source of shoulder pain with variable etiology and pathoanatomical characteristics. Pathological processes of fatty infiltration, muscle atrophy, and fibrosis have all been invoked as causes for poor outcomes after rotator cuff tear repair. The aims of this study were to measure the expression of key genes associated with adipogenesis, myogenesis, a...
متن کاملHeterogeneous muscle gene expression patterns in patients with massive rotator cuff tears
Detrimental changes in the composition and function of rotator cuff (RC) muscles are hallmarks of RC disease progression. Previous studies have demonstrated both atrophic and degenerative muscle loss in advanced RC disease. However, the relationship between gene expression and RC muscle pathology remains poorly defined, in large part due to a lack of studies correlating gene expression to tissu...
متن کاملBiomechanical factors in rotator cuff pathology.
The rotator cuff provides dynamic stability and is critical to normal shoulder function. Forces generated by the rotator cuff facilitate the motions involved in activities of daily living and the more demanding movements of athletics and manual labor. Injury and pathology of the rotator cuff are common and the unique anatomical and biomechanical characteristics of the cuff contribute to the eti...
متن کاملGene expression analysis in calcific tendinopathy of the rotator cuff.
We evaluated the expression of several genes involved in tissue remodelling and bone development in patients with calcific tendinopathy of the rotator cuff. Biopsies from calcified and non-calcified areas were obtained from 10 patients (8 women and 2 men; average age: 55 years; range: 40-68) with calcific tendinopathy of the rotator cuff. To evaluate the expression of selected genes, RNA extrac...
متن کاملOutcomes assessment in rotator cuff pathology: what are we measuring?
BACKGROUND Assessments used to measure outcomes associated with rotator cuff pathology and after repair are varied. This lack of standardization leads to difficulty drawing comparisons across studies. We hypothesize that this variability in patient-reported outcome measures and objective metrics used in rotator cuff studies persists even in high-impact, peer reviewed journals. METHODS All stu...
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ژورنال
عنوان ژورنال: Journal of Bone and Joint Surgery
سال: 2014
ISSN: 0021-9355,1535-1386
DOI: 10.2106/jbjs.m.01585